Title: Glycosyl Hydrolases from the Seeds of Cucurbitaceae
Professor Nadimpalli is a Senior Professor in Biochemistry at University of Hyderabad, Hyderabad, India. He did his postdoctoral training at DAAD, Wuerzburg and Goettingen, Germany, and has been a faculty at University of Hyderabad since 1986.
His glyco-related contributions include development of novel affinity methods to purify mannose 6-phosphate receptors, discovery of LERP from Drosophila and lysosomal enzymes and their receptors in Hydra. He also identified and purified several plant and animal glycosidases, contributed towards understanding the physiological significance of Cucurbitaceae seed lectins and glycosidases.
His Research Interests are (1) Evolution of lysosomal biogenesis; (2) Legume and non-legume lectins-structure-function relationships; (3) Physiological functions of Plant lectins and glycosidases from legumes and non-legumes.
Title: Genome-wide Analysis of Heparan Sulfate Assembly
Dr. Ryan Weiss began his diverse scientific training by earning his B.S. in Chemistry in 2008 at Point Loma Nazarene University in San Diego, CA, USA. He then received his Ph.D. in Chemistry in 2015 at the University of California, San Diego, under the supervision of Prof. Yitzhak Tor, where he studied the design, synthesis, and application of small molecule antagonists of heparin- and heparan sulfate-protein interactions. As an NIH K12 postdoctoral fellow in Prof. Jeffrey Esko’s group at the Department of Cellular and Molecular Medicine at the University of California, San Diego, his research focused on utilizing whole-genome screening methods to investigate the regulation of heparan sulfate biosynthesis. Dr. Weiss began his independent career as an assistant professor at the Complex Carbohydrate Research Center at the University of Georgia in January 2021. Research in the Weiss Laboratory focuses on studying the structure, function, and regulation of complex carbohydrates in human biology and disease. In addition, his lab is dedicated to developing pharmacological and cell-based tools to aid in the discovery of novel targets and approaches for modulating glycan assembly in relevant human disorders.
Professor Yasuhiro Kajihara received his Ph.D. from the Tokyo Institute of Technology in 1993. He spent two years at the Life Science Research Laboratory of Japan Tobacco Inc. as a postdoctoral fellow. In 1995 he joined Yokohama City University as an assistant professor and was then promoted to associate professor in 2001 and full professor in 2007. At YCU, he developed synthetic methods for oligosaccharides and glycoproteins. In 2009, he moved to the Department of Chemistry at Osaka University. He studies new synthetic methods of glycoproteins in order to understand how oligosaccharides regulate protein functions.
Title: Adaptation of Influenza Virus to Human Airway Receptors
James C. Paulson obtained his Ph.D. (Biochemistry) in 1974 from the University of Illinois at Champaign-Urbana and did post-doctoral work at Duke University Medical Centre in Durham, North Carolina, from 1974-78. From 1978-1990 he rose from Assistant Professor to full Professor and vice-chair in the Department of Biological Chemistry at the UCLA School of Medicine, where he developed an interest in analyzing receptor specificity of influenza viruses from different host species. From 1990-1999 he served as Vice President and Member Board of Directors of Cytel Corporation, La Jolla, CA. From 1999-present, he has been Professor, in the Departments of Cell and Molecular Biology, Chemical Physiology, and Immunology and Microbial Sciences at The Scripps Research Institute, in La Jolla, California. He served as acting President & CEO from 2014-2015 and is currently Cecil and Ida Green Professor and Chair of Molecular Medicine. His current research interests include the roles of glycan-binding proteins in the modulation of immune cell signaling and the receptor specificity of mammalian and animal influenza viruses.
Title: C-Mannosylation of Proteins: Specificity and Function
Dr. Hans Bakker is a glycobiologist with expertise in glycosyltransferases. He received his Ph.D. at the VU Amsterdam, the Netherlands, and worked in Zurich, Switzerland, and Wageningen, the Netherlands, afterwards. Since 2001, he has worked at Hannover Medical School in Germany. Over the years, he has identified several new genes encoding glycosyltransferases, including the xylosyltransferases responsible for the glycosylation of Notch EGF repeats and, more recently, the first C-mannosyltransferase, the enzyme responsible for unique glycosylation of tryptophans in proteins. His laboratory has established several specific methods to characterize C-mannosyltransferases and their target proteins from Caenorhabditis elegans and mammals in vitro and cellular systems. After cloning the C-mannosyltransferase in 2013, he could establish that C-mannosylation assists in protein folding in the endoplasmic reticulum and is important for the temperature stability of proteins. Whereas C. elegans has one C- mannosyltransferase, four homologs are present in mammals. His group could show that different mammalian C-mannosyltransferases have distinct fine specificity.
Title: An interface is worth a thousand pictures: An integrated systems approach to glycobiology
Dr. Daniel Bojar is a tenure-track assistant professor at the Wallenberg Centre for Molecular and Translational Medicine & the Department of Chemistry and Molecular Biology at the University of Gothenburg in Sweden, focusing on machine learning and data science in the field of glycobiology. He obtained his Ph.D. in mammalian synthetic biology at ETH Zurich and continued his postdoctoral training in computational biology at MIT & Harvard University. His group develops and applies methods to discover sequence-to-function associations and biological roles of glycans via a broad set of approaches from machine learning, data science, and bioinformatics. Daniel was awarded a Branco Weiss Fellowship - Society in Science, as well as a Foresight Fellowship, and was recognized as a "Rising Star" by the journal Advanced Science. He was also featured on the 2022 Forbes 30 Under 30 Europe list for work in Science & Healthcare.
Title: Making weak antigens strong: exploiting bacterial outer membrane vesicles for delivering glycans to the immune system
Professor Matthew P. DeLisa is the William L. Lewis Professor of Engineering in the School of Chemical and Biomolecular Engineering at Cornell University. His research focuses on understanding and controlling the molecular mechanisms underlying protein biogenesis--folding and assembly, membrane translocation, and post-translational modifications--in the complex environment of a living cell. He received a B.S. in Chemical Engineering from the University of Connecticut in 1996; a Ph.D. in Chemical Engineering from the University of Maryland in 2001; and postdoctoral work at the University of Texas-Austin, Department of Chemical Engineering. DeLisa joined the Department of Chemical and Biomolecular Engineering at Cornell University in 2003. He has also served as a Gastprofessur at the Swiss Federal Institute of Technology (ETH Zürich) in the Institut für Mikrobiologie. He has garnered a number of honors and awards, including most recently the Biotechnology Progress Award for Excellence in Biological Engineering Publication, and was named the to the inaugural “Life Sciences Power 50” by City & State New York. He is an elected fellow of the American Institute for Medical and Biological Engineering, the American Academy of Microbiology, and the American Association for the Advancement of Science. In recent years, he has served on the IDA/DARPA Defense Science Study Group and the National Academies Committee on Innovative Technologies to Advance Pharmaceutical Manufacturing.
Dr. Vered Padler-Karavani received her PhD in biochemistry from Tel Aviv University. She then did her postdoctoral training with Prof. Ajit Varki at The University of California, San Diego (UCSD) and subsequently established The Laboratory for Glycoimmunology at Tel Aviv University The George S. Wise Faculty of Life Sciences, Department of Cell Research and Immunology, The Shmunis School of Biomedicine and Cancer Research. Her research combines glycobiology, immunology, bio-nanotechnology, cancer research and xenotransplantation, and involves cutting edge technologies within these disciplines. She received several prestigious grants from the European Commission (Marie Curie, Health Consortium, ERC) to investigate various aspects of immunology of carbohydrates. With TRANSLINK health consortium (6 academic institutes, 5 hospitals and 3 companies from Israel, Italy, France, Spain, UK, Sweden, Canada and USA; https://cordis.europa.eu/project/id/603049), she investigated risk factors of animal-derived heart valve implants, in ~5,000 patients. Her research is currently focused on studying mechanisms of glycan immune recognition and responses in animal models and in humans, in vitro and in vivo. Particularly, the immunological basis of anti-carbohydrate antibodies and their implications on cancer and heart diseases, and on developing novel diagnostics and therapeutics for such diseases.
Title: Pectic Glycoconjugates in Plant Cell Walls: Working Toward Understanding their Structure, Synthesis and Function
Dr. Debra Mohnen is a Distinguished Research Professor at the Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia. She studies pectin synthesis, structure, and function with an emphasis on the role of pectin in wall architecture and plant cell growth. She was awarded the Bruce Stone Award in 2008 for pectin synthesis and elected as a fellow of the American Association for the Advancement of Science in 2013. Her research on synthesizing pectin glycan backbones, homogalacturonan, and rhamnogalacturonan, led to the discovery of the GAUT and RGGAT families of glycosyltransferases and the finding that pectin is a family of glycan domains in both cell wall heteroglycans and glycoconjugates. Since 2007 part of her research has been directed at improving plant biomass yield, sustainability, and composition for producing biofuel and biomaterials. As Focus Area Lead of Plant Biomass Formation and Modification in the BioEnergy Science Center, she directed a team of researchers aimed at overcoming biomass recalcitrance to deconstruction, and since 2017 she has served as Research Domain Lead for Integrative Analysis and Understanding in the Center for Bioenergy Innovation. Her current focus is understanding the roles of pectin in cell expansion and wall structure.
Title: The gel-forming mucins protecting our intestinal and respiratory tracts are densely glycosylated polymeric proteins
Gunnar C. Hansson, M.D., Ph.D. is a Professor in University of Gothenburg, Sweden. He has been working on mucus, mucins, and mucin glycans his whole career, focusing on the gastrointestinal and respiratory tracts. He has been part of and at the leading edge of developing molecular understanding of mucins over the last 30 years with a focus on their biosynthesis and structure. He and his team discovered that an attached colon mucus layer impenetrable to bacteria separates commensal bacteria from the host and that the chronically diseased lungs are covered with a similar type of mucus. They have studied and discovered that goblet cells making the mucus are more specialized and diverse than previously appreciated. The studied structural variability of glycans on the mucins and their mucin domains are important for commensal bacteria selection and bacterial utilization as a nutritional source. He has founded the Mucin Biology Groups constellation with a total of seven PIs working in the area at the University of Gothenburg (www.medkem.gu.se/mucinbiology).
@TAIPEI, AUG 27~SEP 1 2023
Meet our invited speakers for the Glyco26. To learn more about each individual speaker, please click on the photos below. Speakers are arranged by the first alphabet of surname but starting from a randomized alphabet each time.