Title: Human Gut Bacteria Tailor Extracellular Vesicle Cargo for the Breakdown of Diet- and host-derived glycans
Dr. Feldman obtained his Ph.D. at the University of Buenos Aires, Argentina, under the supervision of Dr. Armando Parodi. After completing his postdoctoral training in Guy Cornelis and Markus Aebi labs in Switzerland, he joined the University of Alberta, in Edmonton, Canada, as an assistant professor. In 2015 he moved to the Department of Microbiology at the Washington University School of Medicine in St Louis, USA. The Feldman lab is interested in microbial glycobiology and bacterial pathogenesis. Dr. Feldman has pioneered the field of bacterial glycoengineering, which is a promising approach for the generation of novel bioconjugate vaccines. He has co-founded two companies (VaxAlta and Omniose) in this area. He is a world leader in studying the human pathogen Acinetobacter baumannii and the biogenesis of bacterial extracellular vesicles. Dr. Feldman is a fellow of the American Academy of Microbiology.
Title: Glycomics-guided glycoproteomics uncovers new players in the innate immune system
Associate Professor Morten Thaysen-Andersen heads the Analytical Glycoimmunology at Macquarie University, Sydney, Australia. Additionally, he was recently recruited as Visiting Professor at Nagoya University, Japan, to set up a Glycoproteomics lab at the prestigious Institute for Glyco-core Research (iGCORE). Across the two laboratories, his glycobiology-focused research program aims to advance our understanding of the human innate immune system and immune-related diseases, including microbial infections, inflammation, and cancer. His team develops and applies novel glycomics and glycoproteomics technologies using advanced mass spectrometry while drawing on analytical tools in protein and carbohydrate chemistry and methods in immunology, structural biology, microbiology, and molecular and cell biology to unravel fundamental glycobiological processes within the innate immune system.
Title: Quantitative descriptions of structure-function relationships of glycoSHIELD of coronavirus spike proteins
Dr. Danny Hsu is a Research Fellow at the Institute of Biological Chemistry, Academia Sinica. During his doctorate study at Utrecht University, the Netherlands, he determined the atomic structure of a lantibiotic, nisin, in complex with Gram-positive bacterial cell wall precursor, Lipid II. He coined the term "pyrophosphate case" to explain how nisin targets Lipid II to achieve its antimicrobial activity, providing a blueprint for future antibiotics developments. During his postdoctoral research at the University of Cambridge, UK, Danny demonstrated the proof of concept of using solution-state NMR spectroscopy to investigate the co-translational folding of nascent polypeptide chains on the ribosome. His earlier independent research focused on the folding mechanisms and functional implications of topologically knotted proteins. He currently focuses on developing an integrated biophysics and structural biology platform, including cryo-electron microscopy, mass spectrometry, and molecular modeling, to investigate the structure-activity relationship (SAR) of glycoproteins, and coronavirus spike proteins, in particular, and how mutations impact on the SAR in the context of glycosylation.
Title: Galectins, Atg8ylation, and Stress Granules in Autophagy and Membrane Stress Response
Dr. Vojo Deretic is the department chair of the Department of Molecular Genetics and Microbiology at the University of New Mexico School of Medicine and the director of the NIH-funded Autophagy, Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence. The AIM center aims to promote autophagy research nationally and internationally and to develop a cadre of junior faculty along with senior experts in this area to study fundamental mechanisms and how autophagy intersects with a broad spectrum of human disease and health states. He received his undergraduate, graduate, and postdoctoral education in Belgrade, Paris, and Chicago. Dr. Deretic’s main contributions to science come from studies by his team on the role of autophagy in infection, immunity, and inflammation. Recently, Dr. Deretic’s group developed the concept of a cellular system termed MERIT for coordinated membrane repair, removal, and replacement. This involves recognition of exposed glycoconjugates on damaged membranes, membrane repair, removal of membranes by autophagy, and replacement of membranous organelles through respective biogenesis programs.
Title: The gel-forming mucins protecting our intestinal and respiratory tracts are densely glycosylated polymeric proteins
Gunnar C. Hansson, M.D., Ph.D. is a Professor in University of Gothenburg, Sweden. He has been working on mucus, mucins, and mucin glycans his whole career, focusing on the gastrointestinal and respiratory tracts. He has been part of and at the leading edge of developing molecular understanding of mucins over the last 30 years with a focus on their biosynthesis and structure. He and his team discovered that an attached colon mucus layer impenetrable to bacteria separates commensal bacteria from the host and that the chronically diseased lungs are covered with a similar type of mucus. They have studied and discovered that goblet cells making the mucus are more specialized and diverse than previously appreciated. The studied structural variability of glycans on the mucins and their mucin domains are important for commensal bacteria selection and bacterial utilization as a nutritional source. He has founded the Mucin Biology Groups constellation with a total of seven PIs working in the area at the University of Gothenburg (www.medkem.gu.se/mucinbiology).
Title: Pectic Glycoconjugates in Plant Cell Walls: Working Toward Understanding their Structure, Synthesis and Function
Dr. Debra Mohnen is a Distinguished Research Professor at the Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia. She studies pectin synthesis, structure, and function with an emphasis on the role of pectin in wall architecture and plant cell growth. She was awarded the Bruce Stone Award in 2008 for pectin synthesis and elected as a fellow of the American Association for the Advancement of Science in 2013. Her research on synthesizing pectin glycan backbones, homogalacturonan, and rhamnogalacturonan, led to the discovery of the GAUT and RGGAT families of glycosyltransferases and the finding that pectin is a family of glycan domains in both cell wall heteroglycans and glycoconjugates. Since 2007 part of her research has been directed at improving plant biomass yield, sustainability, and composition for producing biofuel and biomaterials. As Focus Area Lead of Plant Biomass Formation and Modification in the BioEnergy Science Center, she directed a team of researchers aimed at overcoming biomass recalcitrance to deconstruction, and since 2017 she has served as Research Domain Lead for Integrative Analysis and Understanding in the Center for Bioenergy Innovation. Her current focus is understanding the roles of pectin in cell expansion and wall structure.
Title: Regulation of the Biosynthesis of Glycopeptidolipids in Mycobacterium Abscessus
Dr. Guérardel is a senior researcher for CNRS (Lille University, France) and an Invited Professor at iGCORE (Gifu University, Japan). His research focuses on the structure-to-function relationships of complex carbohydrates, from microorganisms to higher eukaryotes, mostly in the context of host-pathogen interaction. His main objective is to understand how the glycans from both host and pathogen fine-tune the infectious process and how they may be used as diagnosis or therapeutic tools, with a keen interest in mycobacterial, fungus, and viral infections. To reach this goal, Dr. Guérardel integrates a wide range of scientific approaches, including synthetic chemistry, structural analysis using NMR spectroscopy and mass spectrometry, structural biology of proteins, and enzymology.
Title: Regulation and Protein Selectivity of N-Glycan Branching Enzymes
Professor Yasuhiko Kizuka has been a researcher at Disease Glycomics Team, RIKEN, led by Dr. Naoyuki Taniguchi (2009-2017). He has joined Gifu University (Japan) as an Associate Professor since 2017, and is currently the Director and Professor of Integrated Glyco-Molecular Science Center, Institute for Glyco-core Research (iGCORE) at Gifu University.
Professor Kizuka’s glyco-related contributions include discovery of novel mode of catalytic action of glycosyltransferases, elucidation of glycosyltransferase structures and development of glycosyltransferase inhibitors. His Research Interests are (1) Regulation of glycosyltransferase activity; (2) Substrate protein selectivity of glycosyltransferases; (3) Physiological functions of N-glycan branches.
Title: Complex Regulation of domain-specific O-Mannosylation by Three Non-redundant Enzyme Families
Dr. Adnan Halim is a biochemist specializing in mass spectrometry-based glycoproteomics. He obtained his Ph.D. from Gothenburg University, Sweden, in 2012, where he developed methods based on hydrazide chemistry to enrich N- and O-linked glycopeptides from human tissues. This approach led him to discover O-GalNAc linkage to tyrosine residues on amyloid-beta peptides from human cerebrospinal fluid. In 2012, Adnan was recruited to Copenhagen Center for Glycomics (CCG), where he pursued his postdoctoral training and interest in mass spectrometry, protein glycosylations, and precise genome editing. At CCG, Adnan focused on the elusive O-linked mannose modification in eukaryotes. He made major breakthroughs in this field by discovering cadherin/plexin O-mannosylations and the TMTC1-4 glycosyltransferases (GT105). Adnan was promoted to associate professor/group leader at CCG in 2016. Using a combination of techniques, including CRISPR/Cas9 engineering in cell lines and advanced mass spectrometry, his team is currently exploring the functions and regulations of non-classical O-Man glycosylations in mammalian systems.
Title: An interface is worth a thousand pictures: An integrated systems approach to glycobiology
Dr. Daniel Bojar is a tenure-track assistant professor at the Wallenberg Centre for Molecular and Translational Medicine & the Department of Chemistry and Molecular Biology at the University of Gothenburg in Sweden, focusing on machine learning and data science in the field of glycobiology. He obtained his Ph.D. in mammalian synthetic biology at ETH Zurich and continued his postdoctoral training in computational biology at MIT & Harvard University. His group develops and applies methods to discover sequence-to-function associations and biological roles of glycans via a broad set of approaches from machine learning, data science, and bioinformatics. Daniel was awarded a Branco Weiss Fellowship - Society in Science, as well as a Foresight Fellowship, and was recognized as a "Rising Star" by the journal Advanced Science. He was also featured on the 2022 Forbes 30 Under 30 Europe list for work in Science & Healthcare.
@TAIPEI, AUG 27~SEP 1 2023
Travel Award Recipients
To learn more about each individual award recipients, please click on the photos below.
i3S - Institute for Research and Innovation in Health, Portugal
Title: Abnormal Glycosignature of Host Tissue Triggers Pathogenic Recognition Through γδT cells/IL-17a Axis in Autoimmunity.
Inês Alves graduated in Biochemistry from the University of Aveiro. After finishing her master studies, she was awarded an Albert Renolds Travel Grant from the European Foundation for the Study of Diabetes to visit Borsheim’s lab at Arkansas Children’s Research Institute in Little Rock, USA. Inês decided to move to Porto, joining Pinho’s lab where she developed an innovative project on the role of glycans in autoimmunity with the co-supervision Gabriel Rabinovich. During the Ph.D. project, Inês identified an abnormal exposure of microbial-associated glycans in the kidney from lupus nephritis patients, a new glycobiomarker that predicts the development of chronic kidney disease. Her findings were recognized by Pfizer Award 2021 and with a national Prize in autoimmunity research sponsored by the National Group of autoimmunity studies. Inês was awarded an EMBO Scientific Exchange grant in 2021 to develop a novel antigen-specific B cell isolation and culture technique from SLE patients at the Rheumatology lab from LUMC. Inês has also been involved in several international projects, as a member of the consortium funded by the USA Department of Defense grant (GLYCOME PREDICT) and European-funded projects, such as GlycanTrigger (Horizon Europe) and GlycanSwitch (ERC). Moreover, IA is currently the Co-PI of the 2022 Lupus Innovation Award from the Lupus Research Alliance.
Title: Glycomics-assisted Glycoproteomics Enables Insights into the Complex Glycoproteome of Resting and Activated Platelets
The Huong (Kevin) Chau obtained his Bachelor of Advanced Science (2020) and Master of Research (2022) at Macquarie University. During his undergraduate, Kevin joined the Analytical Glycoimmunology research group as a research volunteer. He then started his Master of Research candidature in the group in 2021. Supervised by Associate Professor Morten Andersen, Kevin’s study focused on mapping the glycoproteome of human platelets. At the end of his candidature, he was awarded a University Medal in Chemistry and Biomolecular Science and an International Research Training Program Scholarship funded by the Australian Commonwealth Government for his Ph.D. candidature.
Kevin now continues to pursue his research interest in platelet glycobiology, with his Ph.D. candidature started in July 2022 under the supervision of Associate Professor Morten Andersen and Dr. Rebeca Kawahara. His current project focuses on probing platelet glycosylation and glycan-mediated platelet-neutrophil crosstalk using glycomics and glycoproteomics.
Title: Molecular Details of α2–3-Sialylated O-GalNAc Glycan Recognition by Siglec-like SLBR-N (SLBRUB10712) of Streptococcus gordonii
Dr. Cristina Di Carluccio received her Ph.D. in Chemical Sciences at the University of Naples Federico II (Italy) in 2022 with a final grade of excellent with honors. She is currently a postdoctoral researcher at the Department of Chemical Sciences of the University of Naples Federico II, in the group of Prof. Antonio Molinaro, Prof. Alba Silipo, and Prof. Roberta Marchetti. Her research activity is mainly based on the study of the molecular recognition of eukaryotic and bacterial-derived glycans by different carbohydrate-binding proteins, whose interactions underlie numerous biological processes. During her Ph.D., she deepened her knowledge of advanced NMR techniques and computational methods to study molecular binding from both receptor and ligand perspectives. She also gained experience in the production of recombinant bacterial and mammalian proteins and the NMR characterization of labeled proteins through her secondments at the Charles University of Prague and the Nuclear Magnetic Resonance Centre (CERM) of the University of Florence.
University of Pennsylvania, USA
Title: Investigating the efficacy of Siglec-15 based CAR T-cells.
Nohelly Derosiers is currently a Ph.D. Candidate in the Pharmacology Graduate Group at the University of Pennsylvania. She graduated from the City College of New York with a Bachelor of Engineering in Biomedical Engineering. During her undergraduate career, she worked in the laboratory of Dr. Gilda Barabino, looking into the mechanism of action of L-glutamine therapy for sickle cell disease. Now a member of Dr. Avery Posey Jr.’s laboratory, she is interested in cancer immunotherapy⎯ particularly how the abnormal glycosylation of cancer cells can be exploited to engineer more potent chimeric antigen receptor (CAR) T-cells with improved success against solid malignancies. She hopes to use her knowledge to help render this revolutionary treatment a viable option for a greater number of patients.
Title: Mucin O-glycans Are Host-Derived Immunomodulators of Neutrophil Inflammatory Activity
Jeff Hsiao is a Biological Engineering Ph.D. student in the lab of Katharina Ribbeck at MIT. Trained as an engineer, Jeff has always been curious to unravel the fundamental mechanisms underlying interesting biological phenomena to in turn build tools and therapeutics against diseases. In particular, he is interested in how our immune cells at mucosal surfaces avoid inflammation in health despite constant exposure to exogenous stimulants. Uncovering the basic mechanisms behind this tolerogenic homeostasis will provide insights into treating mucosal inflammatory diseases such as irritable bowel disease and acute respiratory distress syndrome. While extensive research has been performed on factors that alter mucosal immune cell behavior, one overlooked aspect is the influence of the native mucus environment itself. Specifically, how secreted mucins—the main structural proteins of mucus—and their associated mucin O-glycans tune immune cells has been understudied despite recent works demonstrating their signaling potential. In his research, Jeff seeks to address this gap by investigating mucin and mucin O-glycan immunomodulation with a particular focus on innate immune cells. By combining techniques in engineering, immunology, glycobiology, and microbiology, Jeff hopes to discover mechanisms in mucin immunomodulation that can be leveraged to treat inflammatory diseases.
Title: Elucidating the sulfated glycan ligands for Siglec-3 and -8 expressed on Microglia
Dr. Jaesoo Jung has recently attained his Ph.D. under the guidance of Professor Matthew S Macauley, with his research focusing on assessing the influence of carbohydrate sulfation on Siglec ligands. As part of his research project, Jaesoo Jung created a series of U937 cell lines that overexpressed eight distinct carbohydrate sulfotransferases (CHSTs) through lentiviral transduction. To investigate these U937 cell lines that overexpressed CHSTs, Jaesoo Jung also produced a series of human and mouse Siglec-Fc chimeric proteins. His research uncovered that the interaction between Siglecs and their sialic acid-containing ligands (sialosides) could be increased by carbohydrate sulfation. In addition, he created a cell line that expresses a disulfated α2-3 sialyl LacNAc moiety on the cell surface, which has been established as the most strongly bound ligand for CD33 and Siglec-8. Currently, he is using a CRISPR-induced genetic knockout system to investigate the glycosylation pathways responsible for producing sulfated glycan ligands for each Siglec. This method aims to enhance the understanding of the specific pathways and factors that affect Siglec binding to these ligands.
Title: A Cell-Based Production Pipeline for Mammalian Glycopeptides and Glycans
Dr. Thapakorn Jaroentomeechai is a postdoctoral researcher in Prof. Henrik Clausen’s group at the Copenhagen Center for Glycomics (CCG), University of Copenhagen in Denmark. His research focuses on the fundamental roles of carbohydrate-binding molecules and glycobiotechnology. He obtained his Ph.D. in chemical engineering at Cornell University under the supervision of Prof. Matthew P. DeLisa, developing cell-free platforms for glycotherapeutics and vaccine synthesis. Thapakorn was awarded a Royal Thai scholar fellowship, the Cornell CBE Fleming scholar fellowship, as well as the European Molecular Biology Organization (EMBO) postdoctoral fellowship.
Title: Glucosylceramide lysosomal accumulation leads to metabolic alterations underling neuronal degeneration in GCase-related pathologies
Dr. Lunghi is a postdoctoral researcher at the University of Milan, Italy. Starting from her internship as an undergraduate student, Dr. Lunghi had the opportunity to work on the biochemistry of lipids, and in particular on the involvement of sphingolipids in the regulation of neuronal homeostasis and on their implication in several pathologies, including neurodegenerative disorders. During her Ph.D. in Biochemical Sciences (2017-2020) at the Department of Medical Biotechnology and Translational Medicine at the University of Milan, she studied the molecular basis underlying the neurotrophic and neuroprotective properties of ganglioside GM1 and its involvement in sporadic Parkinson’s disease. Her current scientific research is focused on the evaluation of molecular mechanisms on the basis of neurodegeneration occurring in Gaucher disease and in GBA-dependent Parkinson’s disease, with the aim of correlating the lysosomal accumulation of non-catabolized glucosylceramide with the onset of neurodegeneration.
Title: Phyloglycomics: Understanding Species-specific Evolution of the Serum Glycome – a Step Towards Filling the Knowledge Gap in Host-Pathogen Co-Evolution
Abarna Murugan is a Ph.D. student in Professor Daniel Kolarich’s research group at the Institute for Glycomics, Griffith University, Australia. She is keen on understanding the role of host glycans in mediating infection and how evolution has played a role in sculpting the host glycome. Her Ph.D. focuses on understanding host-pathogen co-evolution using state-of-the-art mass spectrometry-based glycomic technology. After completing her bachelor’s in engineering in Biotechnology from Anna University, Chennai, India, she moved to Sweden to pursue her master’s in molecular biology. She was introduced to the field of glycobiology as a young master’s thesis student in Professors Sara Linden and Niclas Karlsson’s labs at the University of Gothenburg, Sweden. Here, she studied the role of glycosylation in mediating bacterial infections in Atlantic Salmon fish. Abarna is motivated in understanding the molecular basis of infectious diseases with the help of novel, sensitive, and rapid mass spectrometry-based experiments.
Title: New StrucGP facilitate precise characterization of glycan modification on site-specific N-glycans
Jiechen Shen is a Ph.D. student at Northwest University and has been joining Shisheng Sun’s lab since 2017. He focuses on the development of new strategies and software for glycoproteomics, especially the strategies for accurate glycan structure interpretation at the intact glycopeptide level. In collaboration with other lab members, Jiechen has developed StrucGP (Nature Methods, 2021) for de novo interpretation of glycan structures on intact N-glycopeptides and applied it to the identification of O-acetylated sialic acid glycopeptides (Analytical Chemistry, 2023). He has received several awards in the glycoscience field during his Ph.D. studies, including the Hui Yongzheng Glycoscience Award and the Outstanding Paper Award for Glycoconjugate.
Graduate School of Science and Engineering, Kagoshima University, Japan
Title: Development of sugar chain binding chimeric antigen receptor expressed natural killer cells for immunotherapy against adult T cell leukemia (ATL)
Dr. Seigo Tateo received his Ph.D. in engineering from Prof. Yasuo Suda’s laboratory at the Department of Graduate School of Science and Engineering, Kagoshima University, Japan. He investigated the development of therapeutic methods against adult T cell leukemia by applying sugar chain binding single-chain variable fragment antibodies in his dissertation. He is now a project researcher working on the Human Glycome Atlas in Prof. Koichi Kato’s laboratory in the Biomolecular Organization Research Group of the Department of Creative Research at the Exploratory Research Center on Life and Systems (ExCELLS), one of the institutes of the National Institute of Nature Science (NINS) in Japan.