Title: Sulfated glycosaminoglycans - Studies in diversity
Dr. Kitagawa received his Ph.D. in Biochemistry in 1991 from Kyoto University. He did his doctoral work in the laboratories of Prof. Ikuo Yamashina and Prof. Toshisuke Kawasaki on the purification and characterization of cancer-associated carbohydrate antigens by using monoclonal antibodies raised against human cancer cells. Dr. Kitagawa went on to do postdoctoral work with Dr. James C. Paulson at Cytel Corporation and Scripps Research Institute. In Dr. Paulson’s laboratory, he worked on the molecular cloning and characterization of several sialyltransferases. In 1994 he obtained an assistant professor position at the Department of Biochemistry, Kobe Pharmaceutical University, where he started to work on the structure and biosynthesis of sulfated glycosaminoglycans. He was promoted to associate professor in 2000 and full professor in 2005. He received the young scientist award of the Japanese Society of Carbohydrate Research in 1999, the PSJ (Pharmaceutical Society of Japan) award for young scientists in 2001, the young investigator award of the Japanese Biochemical Society in 2002, and the PSJ award for Divisional Scientific Promotions in 2013. He has continued to work on the functions and the control of the biosynthesis and degradation of sulfated glycosaminoglycans to clarify the causes of various disorders.
Title: Sialic acid metabolism in the gut microbiota
Dr. Juge has 25-year expertise in the molecular studies of carbohydrate-protein recognition in gut biology and microbiology, and food biotechnology. She is a deputy leader of the Gut Microbes and Health Institute Strategic Programme at the Quadram Institute Bioscience (QIB, Norwich, UK) and an elected fellow of the Royal Society of Biology. Her previous research at Marseille University (France) and Carlsberg Research Institute (Copenhagen, Denmark) focused on the structure-function relationships of plant and microbial carbohydrate-active enzymes and their potential biotechnological application. Since joining QIB in 2007, she has led a Research Group focusing on the Glycobiology of Host-Microbe interactions in the gut. Currently, her group focuses mainly on defining how gut bacteria adapt to the intestinal mucosal environment and the role of mucin glycans in the crosstalk between the gut bacteria and the host. Their work uncovered novel sialic acid metabolism pathways in gut bacteria, contributing to their fitness in the mucus niche and communication with the host. They are also interested in how cell-surface glycosylation of gut symbionts influences the host immune response. Her Lab is involved in initiatives promoting Glycosciences in Europe, such as Sweet Crosstalk or Glytunes multidisciplinary European Training Networks or CarboMet academic-industry network.
Nagoya University Graduate School of Medicine, Japan
Title: Crosstalk of glycosaminoglycans and cell surface receptors in neural wiring/rewiring
Dr. Kadomatsu started his career in basic medical research after being a physician of pediatric neuroblastoma. During his graduate studies, he discovered the glycan-binding growth factor midkine. He has been researching the involvement of cancer, neurology, and inflammation. For this achievement, he received the Young Investigator Award from the Japanese Biochemical Society in 1997.
His research with a Chinese graduate student led him to become particularly interested in the relationship between glycans and the nervous system, which has become the focus of his research. He was a representative of "Neuroglycobiology" (2011-2015), the Grant-in-Aid for Scientific Research on Innovative Areas by the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT). He currently represents the "Human Glycome Project," Roadmap 2020, MEXT.
He served as the President of the Japanese Society of Carbohydrate Research, Editor-in-Chief of the Journal of Biochemistry, and representative of the Asia/Australia/Africa region of the Advance in Neuroblastoma Research Association. He holds an honorary professorship from the Chinese University of Hong Kong.
Professor Tadashi Suzuki received his Ph.D. (1997) from Department of Biochemistry and Biophysics at University of Tokyo, Japan. He demonstrated the activity and characterized the enzymatic properties of the cytoplasmic peptide:N-glycanase (PNGase/Ngly1) mammalian cells and proposed that this enzyme may be involved in the quality control of newly synthesized glycoproteins. Dr. Suzuki was a postdoctoral fellow at Department of Biochemistry and Cell Biology, State University of New York at Stony Brook (1997-2000). He was an Assistant Professor at University of Tokyo (2002-2004) and a Visiting Associate Professor at Osaka University Graduate School of Medicine (2004-2007). During this period, he identified two cytoplasmic glycosidases, endo-beta-N-acetylglucosaminidase (ENGase) and alpha-mannosidase (Man2C1), involved in the catabolism of free glycans released by the cytoplasmic PNGase. He was a Team Leader at Glycometabolome Team, Systems Glycobiology Research Group, RIKEN. He currently serves as a Chief Scientist at Glycometabolic Biochemistry Laboratory, RIKEN Cluster for Pioneering Research.
His current research interests are (1) clarification of the novel catabolic pathway for glycans on glycoproteins; (2) characterization of biological functions of cytoplasmic peptide:N-glycanase (Ngly1) for the non-lysosomal catabolic pathway of N-glycans; (3) development of new analytical methods for glycans; and (4) development of therapeutics for NGLY1-deficiency.
Title: C-Mannosylation of Proteins: Specificity and Function
Dr. Hans Bakker is a glycobiologist with expertise in glycosyltransferases. He received his Ph.D. at the VU Amsterdam, the Netherlands, and worked in Zurich, Switzerland, and Wageningen, the Netherlands, afterwards. Since 2001, he has worked at Hannover Medical School in Germany. Over the years, he has identified several new genes encoding glycosyltransferases, including the xylosyltransferases responsible for the glycosylation of Notch EGF repeats and, more recently, the first C-mannosyltransferase, the enzyme responsible for unique glycosylation of tryptophans in proteins. His laboratory has established several specific methods to characterize C-mannosyltransferases and their target proteins from Caenorhabditis elegans and mammals in vitro and cellular systems. After cloning the C-mannosyltransferase in 2013, he could establish that C-mannosylation assists in protein folding in the endoplasmic reticulum and is important for the temperature stability of proteins. Whereas C. elegans has one C- mannosyltransferase, four homologs are present in mammals. His group could show that different mammalian C-mannosyltransferases have distinct fine specificity.
Title: Adaptation of Influenza Virus to Human Airway Receptors
James C. Paulson obtained his Ph.D. (Biochemistry) in 1974 from the University of Illinois at Champaign-Urbana and did post-doctoral work at Duke University Medical Centre in Durham, North Carolina, from 1974-78. From 1978-1990 he rose from Assistant Professor to full Professor and vice-chair in the Department of Biological Chemistry at the UCLA School of Medicine, where he developed an interest in analyzing receptor specificity of influenza viruses from different host species. From 1990-1999 he served as Vice President and Member Board of Directors of Cytel Corporation, La Jolla, CA. From 1999-present, he has been Professor, in the Departments of Cell and Molecular Biology, Chemical Physiology, and Immunology and Microbial Sciences at The Scripps Research Institute, in La Jolla, California. He served as acting President & CEO from 2014-2015 and is currently Cecil and Ida Green Professor and Chair of Molecular Medicine. His current research interests include the roles of glycan-binding proteins in the modulation of immune cell signaling and the receptor specificity of mammalian and animal influenza viruses.
Title: Targeting Human Viruses with Broadly Protective Low-Sugar Vaccines
Professor Wong received his B.S. and M.S. degrees from National Taiwan University, and Ph.D. (1982) in Chemistry from MIT. He then worked at Harvard University as a postdoctoral fellow, became an assistant professor at Texas A&M University in 1983, and became a professor in 1987. He was Professor and Ernest W. Hahn Chair in Chemistry at the Scripps Research Institute (1989–2006), Director of Genomics Research Center (2003–2006), and President of Academia Sinica (2006-2016). He is currently the Scripps Family Chair Professor of Chemistry at The Scripps Research Institute with a joint appointment at Genomics Research Center, Academia Sinica.
Professor Wong receives numerous awards, including the U.S. Presidential Green Chemistry Challenge Award, the ACS Claude Hudson Award in Carbohydrate Chemistry, Creative Work in Synthetic Organic Chemistry, and the Cope Medal, the Wolf Prize in Chemistry. He is a member of Academia Sinica, the American Academy of Arts and Sciences, and the U.S. National Academy of Sciences.
His research interests are in the field of chemical biology and synthetic chemistry, including the synthesis of complex carbohydrates and glycoproteins associated with disease progression. He is the author of over 700 publications (H-index 144) and 100 patents.
Title: Novel Functions of Polysialic in Kidney Development
Dr. Anja Münster-Kühnel studied Biology and Chemistry in a Teacher Education Programme at the University of Hannover in Germany. After the First State Examination in Biology and Chemistry, she received her Ph.D. at Hannover Medical School (MHH) in the Department of Microbiology by cloning the murine enzyme CMP-sialic acid synthase, an essential enzyme in the biosynthesis of sialoglycoconjugates. As a group leader at the Institute of Clinical Biochemistry, MHH, she continued the molecular characterization of this enzyme and the investigation of its nuclear localization. Further, sialylation-deficient constitutive and conditional mouse models have been generated to unravel the biological function of sialoglycoconjugates in the development and immune system, especially for kidney development and operation. Recently she started to investigate novel functions of polysialic acid beyond the nervous system.
Title: Desialylation GlycoSwitch to Acutely Control Endocytosis
Professor Ludger Johannes is Research Director (DRE) at INSERM. He is a member of the Studienstiftung des Deutschen Volkes (German organization of the academically gifted), Boehringer Ingelheim Fonds, European Molecular Biology Organization (EMBO), and German Academy of Science — Leopoldina. At Institut Curie, he has been heading since 2001 the Traffic, Signaling, and Delivery Team, member of the excellence initiative Cell(n)Scale. Since January 2014, he has directed the Cellular and Chemical Biology unit. His research aims at establishing fundamental concepts of endocytosis and intracellular trafficking. The Johannes team has discovered the membrane trafficking interface between early endosomes and the Golgi apparatus, and demonstrated that lectin-induced glycolipid reorganization acts as a driving force in clathrin-independent endocytosis (termed the GlycoLipid-Lectin / GL-Lect hypothesis). The studies of the Johannes team have been published in highly visible international journals, including Cell and Nature. Between 2014-2020, he was the holder of an ERC advanced grant. He also aims at exploiting the discoveries of his team for the development of innovative cancer therapy strategies using the B-subunit of Shiga toxin (STxB) as a "pilot" for the delivery of therapeutic compounds to precise intracellular locations of dendritic cells for immunotherapy, and to tumors for targeted therapy.
Dr. Linda Hsieh-Wilson is a Professor of Chemistry at the California Institute of Technology. She was born in New York City and obtained her B.S. degree magna cum laude in chemistry from Yale University in 1990. In 1996, she received her Ph.D. in chemistry from the University of California at Berkeley, where she was a National Science Foundation predoctoral fellow in the laboratory of Professor Peter Schultz. In 1996, she moved to Rockefeller University to study neurobiology with Professor and Nobel Laureate Paul Greengard as a Damon Runyon-Walter Winchell postdoctoral fellow. Hsieh-Wilson joined the faculty at the California Institute of Technology in 2000, where she became an associate professor of chemistry in 2006 and a full professor in 2010. She was an Investigator at the Howard Hughes Medical Institute from 2005-2014, and in 2015, she was elected to the American Academy of Arts and Sciences.
Professor Hsieh-Wilson has pioneered the application of organic chemistry to understand the roles of carbohydrates and protein glycosylation in neurobiology. Her honors include a Beckman Young Investigator Award (2000), Research Corporation Research Innovation Award (2000), Alfred P. Sloan Fellowship (2003), Eli Lilly Award in Biological Chemistry (2006), Arthur C. Cope Scholar Award (2008), Gill Young Investigator Award in Neuroscience (2009), and Horace S. Isbell Award in Carbohydrate Chemistry (2014).
@TAIPEI, AUG 27~SEP 1 2023
Meet our invited speakers for the Glyco26. To learn more about each individual speaker, please click on the photos below. Speakers are arranged by the first alphabet of surname but starting from a randomized alphabet each time.
Chang Gung Memorial Hospital and University, Taiwan
Title: Cancer immunotherapy targeting glycosphingolipids (GSLs)
Alice L. Yu, MD, PhD, is an Academician of Academia Sinica, Taiwan. She is a Distinguished Chair Professor & Deputy Director of the Institute of Stem Cell & Translational Cancer Research at Chang Gung Memorial Hospital and Professor Emeritus at the University of California in San Diego.
As a pioneer in cancer immunotherapy, Dr. Yu has taken an anti-GD2 monoclonal antibody (Dinutuximab) from preclinical to phase III clinical trial, culminating in its FDA approval for the treatment of high-risk neuroblastoma in 2015. This marks the first immunotherapeutic agent to target glycolipids worldwide. She has continued to improve the efficacy of anti-GD2 immunotherapy through international collaboration. Her group has demonstrated the adverse impact of Globo H expression on the outcome of patients with hepatoma, cholangiocarcinoma, and gallbladder cancer. She also uncovered the roles of Globo H in cancer as an immune checkpoint molecule and angiogenic factor, providing rationales for the ongoing development of Globo H-targeted immunotherapeutics.
She has received many awards, including the Pediatric Oncology Award from the American Society of Clinical Oncology (ASCO) in 2020, Excellence in Technology Transfer Award from Federal Laboratory Consortium (USA) in 2016, The 55th Academic Award from the Ministry of Education (Taiwan), Year 2000 "Key to Life" Award, Leukemia & Lymphoma Society (USA), etc.
Title: A functional study of O-GlcNAcylation on RNA binding protein RBM14
Professor Won Ho Yang received his Ph.D. from Yonsei University, Seoul, Korea, in 2007. After postdoctoral work in the laboratory of Professor Jamey Marth at the UC Santa Barbara, he joined the Department of Systems Biology, Glycosylation Network Research Center, at Yonsei University as an Assistant Professor in 2019. His research interest is understanding the function of protein glycosylation in normal physiology and the pathogenesis of the disease.