Title: Glycan: A Target for Diagnosis and Treatment of Brain Tumors
Professor Atit Silsirivanit received his Ph.D. in Medical Biochemistry from Khon Kaen University in 2011. During 2014-2016, he was supported by the Japan Society for the Promotion of Science (JSPS) to pursue postdoctoral training at the Department of Tumor Genetics and Biology, Kumamoto University, Japan. His current position is as an Associate Professor of Biochemistry at the Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Thailand. His research focuses on the involvement of glycans and glycosylation in the development and progression of cancers, including cholangiocarcinoma, glioblastoma, meningioma, and melanoma. We are currently working on 1) The role of glycans and glycosylation in cancer, 2) Identification of glycobiomarkers for cancer diagnosis, monitoring, and prognostic prediction, and 3) Application of lectins for detection of glycobiomarkers.
Title: Novel Functions of Polysialic in Kidney Development
Dr. Anja Münster-Kühnel studied Biology and Chemistry in a Teacher Education Programme at the University of Hannover in Germany. After the First State Examination in Biology and Chemistry, she received her Ph.D. at Hannover Medical School (MHH) in the Department of Microbiology by cloning the murine enzyme CMP-sialic acid synthase, an essential enzyme in the biosynthesis of sialoglycoconjugates. As a group leader at the Institute of Clinical Biochemistry, MHH, she continued the molecular characterization of this enzyme and the investigation of its nuclear localization. Further, sialylation-deficient constitutive and conditional mouse models have been generated to unravel the biological function of sialoglycoconjugates in the development and immune system, especially for kidney development and operation. Recently she started to investigate novel functions of polysialic acid beyond the nervous system.
Title: Exploring Glycosylation-dependent Pathways as Modulators of Intestinal Inflammation
Dr. Mariño received her Ph.D. in Chemistry from the University of Buenos Aires. She continued her training as a postdoc at the University of Dundee (Scotland, UK) and later, at the National Institute for Bioprocessing, Research, and Training (Dublin, Ireland), integrating her chemical vision of carbohydrates into the biochemistry of glycans and the structural analysis of glycoconjugates in physiological and pathological contexts. After relocating to Argentina, she established the Functional and Molecular Glycomics Lab (Institute of Biology and Experimental Medicine). As an Independent Researcher at CONICET, she focuses on how inflammatory conditions could alter the glycome in inflammatory bowel diseases and colorectal cancer and whether these changes can promote the establishment of altered lectin-glycan interactions and, in doing so, influence the immune response. Her goal is to capitalize on glycoimmunological mechanisms that could potentially re-wire immune circuits in these pathologies, providing novel opportunities for translational medicine.
Based on her glycoanalytical experience, she also offers consultancies on glycosylation analysis to the Latin American Life Sciences Industry. She received several prizes for her work, including the "Carlos B. Udaondo" award from the National Academy of Medicine (2019). She is the current National Representative for Argentina at the International Glycoconjugate Organization.
Title: The gel-forming mucins protecting our intestinal and respiratory tracts are densely glycosylated polymeric proteins
Gunnar C. Hansson, M.D., Ph.D. is a Professor in University of Gothenburg, Sweden. He has been working on mucus, mucins, and mucin glycans his whole career, focusing on the gastrointestinal and respiratory tracts. He has been part of and at the leading edge of developing molecular understanding of mucins over the last 30 years with a focus on their biosynthesis and structure. He and his team discovered that an attached colon mucus layer impenetrable to bacteria separates commensal bacteria from the host and that the chronically diseased lungs are covered with a similar type of mucus. They have studied and discovered that goblet cells making the mucus are more specialized and diverse than previously appreciated. The studied structural variability of glycans on the mucins and their mucin domains are important for commensal bacteria selection and bacterial utilization as a nutritional source. He has founded the Mucin Biology Groups constellation with a total of seven PIs working in the area at the University of Gothenburg (www.medkem.gu.se/mucinbiology).
Title: Targeting Human Viruses with Broadly Protective Low-Sugar Vaccines
Professor Wong received his B.S. and M.S. degrees from National Taiwan University, and Ph.D. (1982) in Chemistry from MIT. He then worked at Harvard University as a postdoctoral fellow, became an assistant professor at Texas A&M University in 1983, and became a professor in 1987. He was Professor and Ernest W. Hahn Chair in Chemistry at the Scripps Research Institute (1989–2006), Director of Genomics Research Center (2003–2006), and President of Academia Sinica (2006-2016). He is currently the Scripps Family Chair Professor of Chemistry at The Scripps Research Institute with a joint appointment at Genomics Research Center, Academia Sinica.
Professor Wong receives numerous awards, including the U.S. Presidential Green Chemistry Challenge Award, the ACS Claude Hudson Award in Carbohydrate Chemistry, Creative Work in Synthetic Organic Chemistry, and the Cope Medal, the Wolf Prize in Chemistry. He is a member of Academia Sinica, the American Academy of Arts and Sciences, and the U.S. National Academy of Sciences.
His research interests are in the field of chemical biology and synthetic chemistry, including the synthesis of complex carbohydrates and glycoproteins associated with disease progression. He is the author of over 700 publications (H-index 144) and 100 patents.
Title: Regulation and Protein Selectivity of N-Glycan Branching Enzymes
Professor Yasuhiko Kizuka has been a researcher at Disease Glycomics Team, RIKEN, led by Dr. Naoyuki Taniguchi (2009-2017). He has joined Gifu University (Japan) as an Associate Professor since 2017, and is currently the Director and Professor of Integrated Glyco-Molecular Science Center, Institute for Glyco-core Research (iGCORE) at Gifu University.
Professor Kizuka’s glyco-related contributions include discovery of novel mode of catalytic action of glycosyltransferases, elucidation of glycosyltransferase structures and development of glycosyltransferase inhibitors. His Research Interests are (1) Regulation of glycosyltransferase activity; (2) Substrate protein selectivity of glycosyltransferases; (3) Physiological functions of N-glycan branches.
Title: C-Mannosylation of Proteins: Specificity and Function
Dr. Hans Bakker is a glycobiologist with expertise in glycosyltransferases. He received his Ph.D. at the VU Amsterdam, the Netherlands, and worked in Zurich, Switzerland, and Wageningen, the Netherlands, afterwards. Since 2001, he has worked at Hannover Medical School in Germany. Over the years, he has identified several new genes encoding glycosyltransferases, including the xylosyltransferases responsible for the glycosylation of Notch EGF repeats and, more recently, the first C-mannosyltransferase, the enzyme responsible for unique glycosylation of tryptophans in proteins. His laboratory has established several specific methods to characterize C-mannosyltransferases and their target proteins from Caenorhabditis elegans and mammals in vitro and cellular systems. After cloning the C-mannosyltransferase in 2013, he could establish that C-mannosylation assists in protein folding in the endoplasmic reticulum and is important for the temperature stability of proteins. Whereas C. elegans has one C- mannosyltransferase, four homologs are present in mammals. His group could show that different mammalian C-mannosyltransferases have distinct fine specificity.
Title: Altered Glycosylation in Cancer Affects Cellular Receptor Tyrosine Kinases and Regulates Cancer Cell Sensitivity to Therapeutic Drugs.
Celso A Reis is the Head of the Glycobiology in Cancer group at i3S-Institute for Research and Innovation in Health, University of Porto, Portugal. He serves as a member of the Board of Directors of i3S and on the Board of IGO. He is a Professor at the Institute of Biomedical Sciences, University of Porto, and an invited Professor at the Faculty of Medicine of the University of Porto. Celso A Reis has published 227 peer-reviewed papers with over 15400 citations and with an H-index of 56 (Scopus). He is the author of several book chapters and patents. Currently, he leads an international multidisciplinary team working on glycobiology in human diseases focusing on cancer. His lab investigates the molecular mechanisms controlling glycosylation in cancer and the role of glycans during carcinogenesis and tumor progression. He has made several contributions to the development of novel strategies to improve cancer diagnosis, prognosis, and patient stratification. These include the studies on the role of glycosyltransferases regulating the biosynthesis of several glycans involved in cancer, such as those controlling critical steps on mucin-type O-glycosylation and N-glycosylation, with impact in cancer invasion and metastasis, as well as the tumor microenvironment.
Title: Glycomics-guided glycoproteomics uncovers new players in the innate immune system
Associate Professor Morten Thaysen-Andersen heads the Analytical Glycoimmunology at Macquarie University, Sydney, Australia. Additionally, he was recently recruited as Visiting Professor at Nagoya University, Japan, to set up a Glycoproteomics lab at the prestigious Institute for Glyco-core Research (iGCORE). Across the two laboratories, his glycobiology-focused research program aims to advance our understanding of the human innate immune system and immune-related diseases, including microbial infections, inflammation, and cancer. His team develops and applies novel glycomics and glycoproteomics technologies using advanced mass spectrometry while drawing on analytical tools in protein and carbohydrate chemistry and methods in immunology, structural biology, microbiology, and molecular and cell biology to unravel fundamental glycobiological processes within the innate immune system.
Title: Targeting POGLUT1 to Promote Biliary Development in Mouse Models of Alagille Syndrome
Dr. Hamed Jafar-Nejad received his M.D. from Tehran University of Medical Sciences and learned molecular biology techniques at a research institute in Iran. After one year at the University of Ottawa, he moved to Baylor College of Medicine in Houston. He received his postdoctoral training in Notch signaling and Drosophila neurogenesis with Dr. Hugo Bellen. In December 2006, he started his research group, first at the University of Texas Health Science Center-Houston and later at Baylor, where they continued their studies on the role of glycosylation and deglycosylation in animal development. In recent years, the Jafar-Nejad laboratory has devoted significant effort to understanding the function of human rare disease genes in animal development. These collaborative studies have led to the identification of Poglut1 as a dominant genetic suppressor of the liver phenotypes in a mouse model for Alagille syndrome, the identification of a new form of muscular dystrophy caused by recessive mutations in POGLUT1, and the discovery of several pathways downstream of the deglycosylation enzyme N-glycanase 1 (NGLY1), mutations in which cause a multi-system developmental disorder. This work will likely provide novel insight into how glycans regulate animal development and might help establish new therapeutic approaches for these diseases.
@TAIPEI, AUG 27~SEP 1 2023
Meet our invited speakers for the Glyco26. To learn more about each individual speaker, please click on the photos below. Speakers are arranged by the first alphabet of surname but starting from a randomized alphabet each time.