Title: The gel-forming mucins protecting our intestinal and respiratory tracts are densely glycosylated polymeric proteins
Gunnar C. Hansson, M.D., Ph.D. is a Professor in University of Gothenburg, Sweden. He has been working on mucus, mucins, and mucin glycans his whole career, focusing on the gastrointestinal and respiratory tracts. He has been part of and at the leading edge of developing molecular understanding of mucins over the last 30 years with a focus on their biosynthesis and structure. He and his team discovered that an attached colon mucus layer impenetrable to bacteria separates commensal bacteria from the host and that the chronically diseased lungs are covered with a similar type of mucus. They have studied and discovered that goblet cells making the mucus are more specialized and diverse than previously appreciated. The studied structural variability of glycans on the mucins and their mucin domains are important for commensal bacteria selection and bacterial utilization as a nutritional source. He has founded the Mucin Biology Groups constellation with a total of seven PIs working in the area at the University of Gothenburg (www.medkem.gu.se/mucinbiology).
Title: Making weak antigens strong: exploiting bacterial outer membrane vesicles for delivering glycans to the immune system
Professor Matthew P. DeLisa is the William L. Lewis Professor of Engineering in the School of Chemical and Biomolecular Engineering at Cornell University. His research focuses on understanding and controlling the molecular mechanisms underlying protein biogenesis--folding and assembly, membrane translocation, and post-translational modifications--in the complex environment of a living cell. He received a B.S. in Chemical Engineering from the University of Connecticut in 1996; a Ph.D. in Chemical Engineering from the University of Maryland in 2001; and postdoctoral work at the University of Texas-Austin, Department of Chemical Engineering. DeLisa joined the Department of Chemical and Biomolecular Engineering at Cornell University in 2003. He has also served as a Gastprofessur at the Swiss Federal Institute of Technology (ETH Zürich) in the Institut für Mikrobiologie. He has garnered a number of honors and awards, including most recently the Biotechnology Progress Award for Excellence in Biological Engineering Publication, and was named the to the inaugural “Life Sciences Power 50” by City & State New York. He is an elected fellow of the American Institute for Medical and Biological Engineering, the American Academy of Microbiology, and the American Association for the Advancement of Science. In recent years, he has served on the IDA/DARPA Defense Science Study Group and the National Academies Committee on Innovative Technologies to Advance Pharmaceutical Manufacturing.
The research activity of Professor De Castro is in carbohydrate structural chemistry, and her training in this subject started during her bachelor thesis, which focused on plant polysaccharides. Since then, even though Professor De Castro continued her work on carbohydrate structural chemistry, she shifted her interests and dedicated her activity to the analysis of the bacterial membrane carbohydrate components, paying attention, but not limiting the work, to Gram-negative bacteria and lipopolysaccharides (LPSs). This work has resulted in the development of state-of-the-art chemical and spectroscopical approaches that have been later applied with success to different kinds of carbohydrates, such as those from the bacteria of the gut microbiota or those from the giant viruses. This last topic is Professor De Castro's major field of research.
Professor De Castro is the author/co-author of about 130 peer-reviewed publications, an associated Editor for the journal Carbohydrate Polymers, and a member of the editorial board of Carbohydrate Research, Glycobiology, and Polysaccharides. She fruitfully collaborates with different research institutions, such as the Department of Plant Pathology (University of Nebraska Lincoln, NE, USA) and the Structural and Genomics Information Laboratory in Marseille (France).
Title: Fingerprinting disease by mass spectrometry
Professor Manfred Wuhrer studied Biochemistry at Regensburg University and obtained his Ph.D. in 1999 at Giessen University, Germany. Subsequently, he joined the Leiden University Medical Center, where he was appointed assistant professor in 2005 and associate professor in 2008. In 2013, he was appointed full professor of Analytics for Biomolecular Interactions at VU University Amsterdam. In 2015 he continued his career as Head of the Center for Proteomics and Metabolomics at LUMC, Leiden. He focuses on the development of mass spectrometric methods for glycomics and glycoproteomics and their application in clinical research and biotechnology. Clinical applications cover the fields of rheumatoid arthritis, inflammatory bowel disease, colorectal cancer, prostate cancer, longevity, as well as various infectious diseases.
Nagoya University Graduate School of Medicine, Japan
Title: Crosstalk of glycosaminoglycans and cell surface receptors in neural wiring/rewiring
Dr. Kadomatsu started his career in basic medical research after being a physician of pediatric neuroblastoma. During his graduate studies, he discovered the glycan-binding growth factor midkine. He has been researching the involvement of cancer, neurology, and inflammation. For this achievement, he received the Young Investigator Award from the Japanese Biochemical Society in 1997.
His research with a Chinese graduate student led him to become particularly interested in the relationship between glycans and the nervous system, which has become the focus of his research. He was a representative of "Neuroglycobiology" (2011-2015), the Grant-in-Aid for Scientific Research on Innovative Areas by the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT). He currently represents the "Human Glycome Project," Roadmap 2020, MEXT.
He served as the President of the Japanese Society of Carbohydrate Research, Editor-in-Chief of the Journal of Biochemistry, and representative of the Asia/Australia/Africa region of the Advance in Neuroblastoma Research Association. He holds an honorary professorship from the Chinese University of Hong Kong.
Title: New Insights about the Glycan Ligands of Siglecs and their Ability to Control Immune Cells
The primary focus of Dr. Matthew Macauley’s laboratory is the immunomodulatory sialic acid-binding Siglec family of receptors. His group develops innovative approaches to probe Siglec-glycan interactions on cells and tissues and use new insights about the biological ligands of Siglecs to test hypotheses about the roles of Siglecs in controlling immune cell function.
Title: Pectic Glycoconjugates in Plant Cell Walls: Working Toward Understanding their Structure, Synthesis and Function
Dr. Debra Mohnen is a Distinguished Research Professor at the Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia. She studies pectin synthesis, structure, and function with an emphasis on the role of pectin in wall architecture and plant cell growth. She was awarded the Bruce Stone Award in 2008 for pectin synthesis and elected as a fellow of the American Association for the Advancement of Science in 2013. Her research on synthesizing pectin glycan backbones, homogalacturonan, and rhamnogalacturonan, led to the discovery of the GAUT and RGGAT families of glycosyltransferases and the finding that pectin is a family of glycan domains in both cell wall heteroglycans and glycoconjugates. Since 2007 part of her research has been directed at improving plant biomass yield, sustainability, and composition for producing biofuel and biomaterials. As Focus Area Lead of Plant Biomass Formation and Modification in the BioEnergy Science Center, she directed a team of researchers aimed at overcoming biomass recalcitrance to deconstruction, and since 2017 she has served as Research Domain Lead for Integrative Analysis and Understanding in the Center for Bioenergy Innovation. Her current focus is understanding the roles of pectin in cell expansion and wall structure.
Title: Glycans at the Frontiers of Inflammation, Autoimmunity and Cancer: mechanisms and clinical implications.
Salomé Pinho is the coordinator of the research group "Immunology, Cancer & GlycoMedicine" at the Institute for Research and Innovation in Health (i3S) at the University of Porto, Portugal, and affiliated Professor at the Medical Faculty of the University of Porto, Portugal. She developed her Ph.D. research at the Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) and Boston University Medical School, MA, USA. She performed her postdoctoral work at IPATIMUP-University of Porto in the cancer glycobiology field. Early in her career, Dr. Pinho established a research line focusing on glycoimmunology in Inflammatory Bowel Disease. Her group focuses on understanding the role of post-translational modifications by glycosylation in the regulation of key proteins´ functions involved in cancer and chronic inflammatory conditions, envisioning potential clinical applications.
She is the Principal Investigator of several national/international grants in cancer glycobiology and inflammatory diseases. She received the Young Investigator Award from the European Association for Cancer Research and was recently distinguished by the Society for Glycobiology with the 2020 Glycobiology Significant Achievement Award.
Title: Protein-Carbohydrate Interactions in Infection and Cancer Biology
Dr. Ute Krengel studied Chemistry in Göttingen (Germany) and obtained her Ph.D. from the University of Heidelberg in 1991 (structure and molecular mechanism of p21ras). After positions in Toronto (Canada), Groningen (The Netherlands), and Gothenburg (Sweden), she moved to Oslo (Norway), where she has held a full Professorship since 2006. She is particularly interested in molecular mechanisms of diseases, including infectious diseases and cancer, focusing on receptor interactions and enzymes. She currently serves as the Norwegian Block Allocation Group for Synchrotron Research coordinator and as a Norwegian representative of the International Glycoconjugate Organization.
Professor Tadashi Suzuki received his Ph.D. (1997) from Department of Biochemistry and Biophysics at University of Tokyo, Japan. He demonstrated the activity and characterized the enzymatic properties of the cytoplasmic peptide:N-glycanase (PNGase/Ngly1) mammalian cells and proposed that this enzyme may be involved in the quality control of newly synthesized glycoproteins. Dr. Suzuki was a postdoctoral fellow at Department of Biochemistry and Cell Biology, State University of New York at Stony Brook (1997-2000). He was an Assistant Professor at University of Tokyo (2002-2004) and a Visiting Associate Professor at Osaka University Graduate School of Medicine (2004-2007). During this period, he identified two cytoplasmic glycosidases, endo-beta-N-acetylglucosaminidase (ENGase) and alpha-mannosidase (Man2C1), involved in the catabolism of free glycans released by the cytoplasmic PNGase. He was a Team Leader at Glycometabolome Team, Systems Glycobiology Research Group, RIKEN. He currently serves as a Chief Scientist at Glycometabolic Biochemistry Laboratory, RIKEN Cluster for Pioneering Research.
His current research interests are (1) clarification of the novel catabolic pathway for glycans on glycoproteins; (2) characterization of biological functions of cytoplasmic peptide:N-glycanase (Ngly1) for the non-lysosomal catabolic pathway of N-glycans; (3) development of new analytical methods for glycans; and (4) development of therapeutics for NGLY1-deficiency.
@TAIPEI, AUG 27~SEP 1 2023
Meet our invited speakers for the Glyco26. To learn more about each individual speaker, please click on the photos below. Speakers are arranged by the first alphabet of surname but starting from a randomized alphabet each time.